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Design and Development Challenges of Natural Products Certified Reference Solutions
Authors: Tamara Tarbox, Isil Dilek, Derrell Johnson, and Mitzi Rettinger
Presented at Association of Official Analytical Chemists (AOAC), Las Vegas, NV, October 2012
Abstract
Laboratories often encounter multiple technical challenges in natural products testing of botanicals such as Ginkgo biloba, Ginseng, and Green tea. These phytochemicals offer significant handling issues due to inherent problems with hygroscopicity or sensitivity to air and/or light, which makes preparation of an accurate and consistent reference standard problematic. Weighing accuracy of milligram amounts of phytochemicals can be negatively affected by balance environment and weighing technique. Without consideration of proper diluent selection and controls in weighing, handling and solution preparation, accuracy and stability of phytochemical solution reference standards can be impacted. This poster will discuss these factors and their influence on the design, preparation, and certification of selected multi-component phytochemical solution standards.
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