ST. LOUIS – October 8, 2015 – Sigma-Aldrich Corporation
(NASDAQ: SIAL) announced today that the Cerilliant® brand within its
Applied Diagnostics and Testing business segment has launched its new bile acid
reference standards product line with ten certified Snap-N-Spike® solutions
of the most routinely tested bile acids and their stable-labeled internal
standards. These new solution Certified Reference Materials (CRMs) consist of
lithocholic acid, taurocholic acid and native and deuterium-labeled analogs of
cholic acid, chenodeoxycholic acid, deoxycholic acid, and ursodeoxycholic acid.
Mass spectrometry-based analyses of bile acids (BAs) are
performed in neonatal screening of inborn errors of BA synthesis and therapeutic
monitoring of patient responses to therapy.1 BA analysis is also
routinely conducted during the pre-clinical phase of drug development to
evaluate the hepatotoxicity of candidate drugs.2
Research highlighting the influence of BA metabolism in the
development of gastroenterologic and hepatic diseases has led to the need for
new BA testing applications.3,4 These emerging applications include
the use of BAs as biomarkers for the detection of biliary tract cancer,
metabolic profiling of patients with gastrointestinal disorders to optimize
treatment outcomes, and identifying additional biomarkers for liver diseases
such as obstetric cholestatis, a liver disorder associated with adverse
perinatal outcomes.3,4,5
Cerilliant offers a wide selection of Certified Spiking
Solutions® for use as starting material in the preparation of
calibrators and controls in testing applications ranging from clinical
diagnostic testing, endocrinology, and clinical chemistry to therapeutic drug
monitoring, clinical toxicology, and pharmaceutical research. Cerilliant’s
catalog offering includes solution CRMs of numerous native and stable-labeled
drugs and drug metabolites, as well as endogenous biomarkers. Cerilliant
certified reference solutions are manufactured and certified to the highest
industry standards including ISO Guide 34, ISO/IEC 17025, and ISO 13485 and are
compliant with ISO 15194.