In the February, 2013, issue of the Journal of Analytical and Bioanalytical Chemistry, Cerilliant published a feature article titled “Development Challenges in the Preparation of Solution-based Phytochemical and Vitamin Certified Reference Materials.” Authors include: Derrell Johnson, Mitzi Rettinger, Tamara Tarbox, Beth Marek, Sherri Pogue, Isil Dilek, and Uma Sreenivasan.

The changing regulatory landscape for dietary supplements has highlighted the importance of accurate Certified Reference Materials (CRMs) in quality control testing of the final product. Phytochemical and vitamin reference materials offer unique challenges in characterization and handling that could affect accuracy of the reference material as well as the results obtained from its use.

This paper examines the impact of neat material characterization, pre-formulation studies, and long-term stability on the design and development of vitamin and phytochemical solution-based CRMs. Inappropriate consideration of the above parameters could result in inaccurate quantitation due to improper weighing adjustment of the neat material and insolubility or degradation of the analyte of interest in solution. CRMs of vitamins and phytochemicals in a single use, ampouled solution standard format present a suitable option for analytical testing in the food and dietary supplement industries.   

For access to the complete article, please visit: Development challenges in the preparation of solution-based phytochemical and vitamin certified reference materials