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Cerilliant Article The Uncertainty of Reference Standards Published in Journal of Analytical Toxicology, October 2009
The Uncertainty of Reference Standards – A Guide to Understanding Factors Impacting Uncertainty, Uncertainty Calculations, and Vendor Certifications Authors: Kevin Gates, Ning Chang PhD, Isil Dilek PhD, Huahua Jian PhD, Sherri Pogue, Uma Sreenivasan PhD
Certified Solution Standards are widely used in forensic/toxicology, clinical/diagnostic, and environmental testing. Typically, these standards are purchased as ampouled solutions with a certified concentration. Vendors present concentration and uncertainty differently on their Certificates of Analysis. Understanding the factors that impact uncertainty and which factors have been considered in the vendor’s assignment of uncertainty are critical to understanding the accuracy of the standard and the impact on testing results. Understanding these variables is also important for laboratories seeking to comply with ISO/IEC 17025 requirements and for those preparing reference solutions from neat materials at the bench.
The impact of uncertainty associated with the neat material purity (including residual water, residual solvent and inorganic content), weighing techniques, and preparation of the solution standard on the overall uncertainty of the certified concentration will be presented along with uncertainty calculations. For access to the complete article please visit JAT - Cerilliant Uncertainty of Reference Standards Paper.
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