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Research Suggests Intravenous Ketamine Reduces Suicidality in Depressed Patients
In the September 1, 2009, issue of Biological Psychiatry, researchers at Rutgers
University examined Ketamine’s effects on suicidality in patients with treatment-resistant
depression. Previously used as an anesthetic, Ketamine has shown rapid antidepressant
effects in early trials when applied intravenously. (http://www.journals.elsevierhealth.com/periodicals/bps/article/S0006-3223(09)00519-8/abstract)
In a preliminary study with a small group of depressed patients, the results demonstrated
an acute reduction in suicidal thoughts when patients were assessed 24 hours after
a single intravenous (IV) injection of Ketamine. The observed reduction in suicidality
was maintained over the next two weeks when patients received repeated doses.
According to corresponding author Rebecca Price, IV Ketamine treatment could provide
an alternative treatment option in cases where the patient’s life might be endangered
by waiting for conventional antidepressant treatments to take effect. In some cases,
drug treatment options for depression can take weeks for the beneficial effects
to emerge, which is greatly inadequate for patients with a high risk of immediate
suicide.
Price cautioned that the findings from these early trials must also be observed
in larger samples of patients with a high suicide risk. The findings present tremendous
promise, however, and could potentially foster improved treatment options for suicidal
patients in the future.
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